The reference site for Clindamycin

Clindamycin is an antibiotic useful for the treatment of a number of bacterial infections. This includes middle ear infections, bone or joint infections, pelvic inflammatory disease, strep throat, pneumonia, and endocarditis among others.

WHAT IS Clindamycin?

Clindamycin is used primarily to treat infections caused by susceptible anaerobic bacteria. Such infections might include respiratory infections, septicemia and peritonitis. In patients with hypersensitivity to penicillins, clindamycin may be used to treat susceptible aerobic infections as well.

Additionally, topical application of clindamycin phosphate can be used to treat severe acne due to its bacteriostatic effect. Clindamycin interferes with bacterial protein synthesis, in a similar way as erythromycin and chloramphenicol, by binding to the 50S subunit of the bacterial ribosome.

Clindamycin is also used to treat bone-infections caused by staphylococcus aureus.

This medication is marketed under various trade names including Dalacin® (Pfizer), Cleocin® (Pfizer) and Evoclin® (Connetics) – in a foam delivery system.

 

Brand Name(s): Cleocin Oral; Cleocin T; Evoclin;Duac Topical (with benzoyl peroxide)
CAS nº: 18323-44-9
(clin da mye sin)

 

Product Info

The sections below will provide you with more specific information and guidelines related to clindamycin and its correct use. Please read them carefully.

FDA Information

Clindamycin was approved by the FDA in 1970 and is marketed as the hydrochloride salt for oral administration and as the phosphate salt for parenteral, topical or vaginal administration.

Why is this medication prescribed?

Clindamycin is used primarily to treat infections caused by susceptible anaerobic bacteria. Such infections might include respiratory infections, septicemia and peritonitis. In patients with hypersensitivity to penicillins, clindamycin may be used to treat susceptible aerobic infections as well.

It is also used to treat bone-infections caused by staphylococcus aureus.

Additionally, topical application of clindamycin phosphate can be used to treat severe acne.

It is most effective against infections involving the following types of organisms:

– Aerobic gram-positive cocci, including some members of the Staphylococcus and Streptococcus (eg. pneumococcus) genera.

– Anaerobic gram-negative bacilli, including some members of the Bacteroides and Fusobacterium genera.

Mechanism: clindamycin has a bacteriostatic effect. Clindamycin interferes with bacterial protein synthesis, in a similar way as erythromycin and chloramphenicol, by binding to the 50S subunit of the bacterial ribosome.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

USAGE

For patients taking the capsule form of clindamycin:

The capsule form of clindamycin should be taken with a full glass (8 ounces) of water or with meals to prevent irritation of the esophagus (tube between the throat and stomach).

For patients taking the oral liquid form of clindamycin:

Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

Do not use after the expiration date on the label. The medicine may not work properly after this date. Check with your pharmacist if you have any questions about this.

To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days. If you have a “strep” infection, you should keep taking this medicine for at least 10 days. This is especially important in “strep” infections. Serious heart problems could develop later if your infection is not cleared up completely. Also, if you stop taking this medicine too soon, your symptoms may return.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at evenly spaced times day and night . For example, if you are to take 4 doses a day, doses should be spaced about 6 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

DOSAGE

The dose of clindamycin will vary for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of clindamycin. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules or teaspoonfuls of solution that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking clindamycin.

For oral dosage forms (capsules and solution):

Adults and teenagers – 150 to 300 milligrams (mg) every six hours.

Children:
Infants up to 1 month of age – use and dose must be determined by your doctor.

Infants and children 1 month of age and older – dose is based on body weight. The usual dose is 2 to 5 mg per kilogram (kg) (0.9 to 2.3 mg per pound) of body weight every six hours; or 2.7 to 6.7 mg per kg (1.2 to 3.0 mg per pound) of body weight every eight hours.

For injection dosage form:

Adults and teenagers – 300 to 600 mg every six to eight hours injected into a muscle or vein; or 900 mg every eight hours injected into a muscle or vein.

Children:
Infants up to 1 month of age – dose is based on body weight. The usual dose is 3.75 to 5 mg per kg (1.7 to 2.3 mg per pound) of body weight every six hours injected into a muscle or vein; or 5 to 6.7 mg per kg (2.3 to 3.0 mg per pound) of body weight every eight hours injected into a muscle or vein.

Infants and children 1 month of age and older – dose is based on body weight. The usual dose is 3.75 to 10 mg per kg (1.7 to 4.5 mg per pound) of body weight every six hours injected into a muscle or vein; or 5 to 13.3 mg per kg (2.3 to 6.0 mg per pound) of body weight every eight hours injected into a muscle or vein.

What special precautions should I follow?

Before taking Clindamycin:

Tell your doctor if you have liver disease, kidney disease, or stomach or intestinal disease. You may not be able to take clindamycin, or you may require a dosage adjustment or special monitoring during treatment, if you have any of the conditions listed above.

It is not known whether clindamycin will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Clindamycin passes into breast milk and may affect a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Take the missed dose as soon as you remember, then take the rest of the day’s doses at evenly spaced intervals unless otherwise directed by your doctor. If you don’t remember until it is almost time for the next dose, skip the missed dose and take the next regularly scheduled dose as directed.

Do not take a double dose unless otherwise directed by your doctor.

What side effects can this medication cause?

Side effects from clindamycin may include:

diarrhea (mild)
nausea and vomiting
stomach pain
itching of rectal or genital (sex organ) areas

Tell your doctor if any of these symptoms are severe or do not go away:

abdominal or stomach cramps and pain (severe)
abdominal tenderness
diarrhea (watery and severe or bloody)
fever

If you experience any of the following symptoms, call your doctor immediately:

an allergic reaction (swelling of the lips, tongue, or face; shortness of breath; closing of the throat; or hives);
a rash
diarrhea
yellowing of the skin or eyes
abdominal pain
little or no urine

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Do not refrigerate the oral liquid form of clindamycin. If chilled, the liquid may thicken and be difficult to pour. Follow the directions on the label.

Throw away any medication that is outdated or no longer needed, and should you have any doubts please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of a clindamycin overdose are not well known, but the following may be expected:

abdominal pain
nausea
vomiting
diarrhea

Product Images

PICTURES OF CLINDAMYCIN PILLS

Below you will find images and specific information on the principal types of clindamycin that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: CLEOCIN HCL®

Strength(s): 75 MG

Imprint: CLEOCIN 75 mg

Manufacturer: PHARMACIA/UPJHN.

Name: CLINDAMYCIN

Strength(s): 150 MG

Imprint: cor 153

Manufacturer: SANDOZ

Name: CLINDAMYCIN

Strength(s): 150 MG

Imprint: DAN 5708

Manufacturer: WATSON LABS.

Name: CLINDAMYCIN

Strength(s): 150 MG

Imprint: 93 3171

Manufacturer: TEVA USA

Name: CLINDAMYCIN

Strength(s): 150 MG

Imprint: 150 mg 3328

Manufacturer: GREENSTONE LTD.

Name: CLINDAMYCIN

Strength(s): 150 MG

Imprint: RX692

Manufacturer: RANBAXY

Name: CLEOCIN HCL®

Strength(s): 300 MG

Imprint: CLEOCIN 300 mg

Manufacturer: PHARMACIA/UPJHN.

Name: CLINDAMYCIN

Strength(s): 300 MG

Imprint: cor 154

Manufacturer: SANDOZ

Name: CLINDAMYCIN

Strength(s): 300 MG

Imprint: RX693

Manufacturer: RANBAXY

Name: CLINDAMYCIN

Strength(s): 300 MG

Imprint: DAN 3120

Manufacturer: WATSON LABS.

Name: DUAC® TOPICAL GEL

Strength: Clindamycin 1%, Benzoyl Peroxide 5%

Imprint: Duac Topical Gel

Manufacturer: STIEFEL LABORATORIES INC.

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